1st research article from htt:\/\/www.jci.org on March 24, 2018
\n– Proapoptotic Puma targets stem-like breast cancer<\/p>\n
and the second research article from –<\/p>\n
JCI – Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
\nby:
\nBrian D. Lehmann, Joshua A. Bauer, Xi Chen, Melinda E. Sanders, A. Bapsi Chakravarthy, Yu Shyr, Jennifer A. Pietenpol -Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
\nBio 1900 Research Paper Topic
\nInformation about the Requirements for this Paper
\n\u2022 You must write a 1500 word essay in order to fulfill the course writing requirement established by the college to demonstrate writing proficiency. The 1500 word limit does not include the title page, abstract, or your references cited list.<\/p>\n
\u2022 Your paper will cover a human genetic disorder. There must be a genetic component to the disorder you choose to write about.<\/p>\n
\u2022 You will include at least 5 references in a references cited list at the end of your paper.<\/p>\n
\u2022 You will reference at least 2 original research papers or reviews as a part of your research paper sources.
\nRefer to the Research Paper Information folder on the portal for how to find original research papers.
\n_________________________________________________________________________________________________<\/p>\n
Your Research Paper Topic- Assignment Details<\/p>\n
1. Fill out the section below indicating your topic and show me that there should be sufficient resources for you to reference.
\n2. Find and upload 2 original research articles on your topic. I am asking your all to demonstrate that you can accomplish this so you will be able to find the right type of references for your paper early in the semester before the paper is due. You must upload at least 3 documents in order to complete this assignment. 1. This form filled out, 2. And 3. are PDFs of research articles on your topic.
\n\u2022 You will need to reference the files in the research paper information folder on the portal in order to complete this section.<\/p>\n
Type your answers into the blanks as requested and upload the file or scan and upload the file.
\nStudent Name __________________________________
\nProposed Topic _________________________________
\nType your proposed topic into the search box on the google scholar website (www.scholar.google.com) How many hits does your topic generate in google scholar? ________________________________
\nMy recommendation is that you should not choose a topic that generates fewer than 50,000 hits on google scholar. If you are really interested in a topic and it generates fewer hits, consider writing a paper comparing the disorder or disease to another similar disorder. If you decide to include multiple topics, tell me about your idea and provide me the number of hits on google scholar that each topic generates.
\nUse the space below if you want to explain more about your proposed idea. If it is not clear to me, there is a chance I will tell you that it does not meet the above criteria.<\/p>\n
.<\/p>\n
Research Paper Citation Requirements
\n\u202210 points of your paper are from the citation of 2 original research articles. You will upload the pdfs of these articles with your paper.
\n\u2022You must use at least 5 sources for your paper
\n\u20225 points
\n\u20225 points for correct format.
\n\u202220 total points for references
\nWithin Text Citations
\n\u2022You must also reference your citations within the text of your document.
\n\u2022For example-
\n\u2022\u201cSmall cell carcinoma lung cancer has a less than 5% five year survival rate (Jones and Smith, 2012)\u201d.
\n\u2022Then in your references list-
\n\u2022The full citation for Jones and Smith 2012 should be listed in your references list at the end of your paper.<\/p>\n
Research Paper Assignment
\n\u2022The paper must be at least 1500 words.
\n\u2022Your papers should focus on covering a human genetic disorder.
\n\u2022Human diseases are complicated, but in order for your topic to be approved, your topic must contain at least some genetic component.
\n\u2022You can\u2019t just cover cancer, for example.
\n\u2022 You may choose to write your paper on a form of cancer that we know has a genetic component, for example, breast or colon cancer.<\/p>\n
Resources to find research paper topics<\/p>\n
\u2022List of human genetic disorders:
\n\u2022 https:\/\/en.wikipedia.org\/wiki\/List_of_genetic_disorders<\/p>\n
\u2022List of genetic cancers and known genes:
\n\u2022 http:\/\/www.facingourrisk.org\/understanding-brca-andhboc\/information\/hereditary-cancer\/othergenes\/basics\/hereditary-cancer-by-cancer-type.php<\/p>\n
Research Paper Assignment
\n\u2022You must address the following points:
\n1. Describe the disease\/condition.
\n2. You will need to understand some of the biology of the body region or organ which is(are) affected by the disease\/condition.
\na) If you write about breast cancer, you will need to understand the circulatory and lymphatic systems and adipose tissue, etc\u2026
\nb) If you write about Wilson\u2019s Disease, a genetic brain disorder, you will need to understand some neuroanatomy.
\nResearch Paper Assignment
\n\u2022You must address the following points:
\n3. What is known about the genetics of the disease? It is dominant or recessive? Autosomal or sex linked? Does it result from a mistake during meiosis? Is it variably expressed? Multifactorial?
\n4. What is the biochemical\/cellular basis for the disease? Are there treatments?<\/p>\n
Research Paper Assignment
\n\u2022You may also include:
\n5. What is the history of the disease? Was it known historically? Were any important people in history afflicted with the disease?
\n6. How many people have this disease? Is it a big social problem?
\n7. Is there a genetic test to diagnose this disease? How does it work? How accurate is the test?<\/p>\n
Grading Criteria<\/p>\n
\u2022The following will determine your grade for this paper. I will look for:
\n\u2022Adherence to the content specifications (approx. 40%)
\n\u2022Adherence to the technical specifications (approx. 20%)
\n\u2022Proper use of citations and the citation of 2 original research articles (approx. 20%).
\n\u2022Accuracy and understanding of material presented in the paper (approx. 20%)
\nDefinition of a review\/research paper
\n\uf0b7 A review is a comprehensive synthesis of results from a wide and complex set of studies
\n\uf0b7 A synthesis of findings rather than ideas
\n\uf0b7 Goal of a review paper is to help readers make sense of all available information
\n\uf0b7 Direct quotations rarely found in reviews. DO NOT ADD TO THE LENGTH OF YOUR PAPER BY
\nQUOTING DIRECTLY FROM ANY SOURCE. I WILL NOT COUNT QUOTES TOWARD YOUR TOTAL
\nWORD COUNT!!
\nResearch reviews focus on primary sources
\n\uf0b7 Original scientific experimentation reported in scientific journals
\n\uf0b7 The quality of the review depends largely on the comprehensiveness of the literature search
\nUse of secondary sources\u2014textbooks, books or magazine articles (Scientific American, Discover)
\nOutline of a review\/research paper
\n\uf0b7 Title Page
\n\uf0b7 Title should be specific, informative, concise
\n\uf0b7 Abstract
\n\uf0b7 Short, concise summary of paper (200-250 words)
\n\uf0b7 No references
\n\uf0b7 Center “Abstract” a double space before paragraph
\n\uf0b7 Introduction
\n\uf0b7 Center “Introduction” above this section
\n\uf0b7 Review the topic
\n\uf0b7 Importance and significance
\n\uf0b7 Background information, conflicting views, major lines of thought
\n\uf0b7 Statement of purpose
\n\uf0b7 Document and reference sources
\n\uf0b7 Body of text (topic 1, topic 2, Topic 3)
\n\uf0b7 Present details of work done by researchers on topic
\n\uf0b7 Mention and describe important techniques, methods, results, and conclusions
\n\uf0b7 May have headings, but don’t use “Body”
\n\uf0b7 Useful headings include- history of X disease, treatment of X disease, etc\u2026
\n\uf0b7 Develop and follow good topic sentences
\n\uf0b7 Coherent, well-blended summation of all the work you could find that is important to your
\nsubject
\n\uf0b7 Develop a pathway of thought that leads to conclusions
\n\uf0b7 Document and reference sources
\n\uf0b7 Conclusions
\n\uf0b7 Consolidate ideas, strengthen relationships between ideas, patterns, tie up loose ends
\n\uf0b7 Significance of topic
\n\uf0b7 Make sure you conclude something
\n\uf0b7 Do not introduce new data, results
\n\uf0b7 What is next, future avenues of research
\n\uf0b7 Person\/Tense
\n\uf0b7 Most scientific work is written in the third person, but is written in passive, past tense
\n\uf0b7 Avoid using pronouns
\n\uf0b7 Facts and ideas are stated about procedures and results. Comparative studies were
\nperformed —- or —- was observed over a period of two years
\nFormatting your Paper
\nGeneral Information
\n\uf0b7 1500 words of text- your title page, abstract, and references do not count toward your word total
\n\uf0b7 Typed, double-spaced
\n\uf0b7 12 point serif type fonts (Times, Times New Roman, Palatino, Calibri (the font used in this
\ndocument))
\n\uf0b7 Margins 1″ left, 1″ top, 1″ right, 1″ bottom
\n\uf0b7 Indent each new paragraph 0.25″
\nTitle Page
\n\uf0b7 Center title about 1\/3 down the page in 18-point font. Capitalize the first letter of each word except
\nfor articles (a, an, the), conjunctions (and, but, for) and prepositions (in, on, to)
\nFor Example:
\nThe Effect of Type I Diabetes on Juvenile Patients
\n\uf0b7 Center your name 10 lines under the title in 12-point font
\n\uf0b7 Center the date of submission date a double space below your name in 12-point font
\nPagination
\n\uf0b7 Number the pages consecutively, beginning with the first page of text
\n\uf0b7 Use only Arabic numbers (1, 2, 3, etc.)
\n\uf0b7 Put the page numbers centered at the bottom of each page
\nHeadings
\n\uf0b7 Use sparingly
\n\uf0b7 Make them informative and concise (Do not use Body as a heading)
\n\uf0b7 Center headings
\n\uf0b7 Triple space before the heading and double space after the heading (triple does not mean 3 hard
\nreturns when using double spacing- this leaves 6 lines between each chunk of text)
\n\uf0b7 Use 12-point bold font<\/p>\n","protected":false},"excerpt":{"rendered":"
1st research article from htt:\/\/www.jci.org on March 24, 2018 – Proapoptotic Puma targets stem-like breast cancer and the second research article from – JCI – Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies Read More …<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-427178","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/posts\/427178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/comments?post=427178"}],"version-history":[{"count":0,"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/posts\/427178\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/media?parent=427178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/categories?post=427178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.benedictsol.com\/blogs\/wp-json\/wp\/v2\/tags?post=427178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}